Science

DNA, rewrit­ten as medicine.

DNA is the foun­da­tion­al infor­ma­tion lay­er of biol­o­gy: direct­ing the pro­duc­tion of RNA and pro­teins to car­ry out cel­lu­lar func­tions. Until now, DNA could not be used as a med­i­cine because of its immuno­genic­i­ty and inef­fi­cient access to the cell’s nucle­us. Serif Bio­med­i­cines over­came these chal­lenges by reshap­ing DNA’s form and func­tion so it works with these bar­ri­ers, not against them.

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How Mod­i­fied DNA works

Trans­form­ing DNA from blue­print into therapeutic.

Serif cre­at­ed Mod­i­fied DNA by alter­ing the struc­tur­al and chem­i­cal form of DNA to min­i­mize innate immuno­genic­i­ty dur­ing deliv­ery into cells. Mod­i­fied DNA reverts to unmod­i­fied DNA once inside the nucle­us, enabling tran­scrip­tion into ther­a­peu­tic RNA and proteins.

Enhanced with mRNA co-factors

Enabling durable ther­a­peu­tic expression

Serif has devel­oped mRNA co-fac­tors that are deliv­ered with Mod­i­fied DNA and tran­sient­ly express pro­teins that enhance nuclear entry and gene expression.

Mod­i­fied DNA com­bines the best fea­tures of mRNA and gene ther­a­py while
mit­i­gat­ing their limitations.

Mod­i­fied DNA med­i­cines are designed to last longer, be giv­en more than once, and be pro­grammed for cell-spe­cif­ic expres­sion. Built on a scal­able plat­form, Mod­i­fied DNA has the fea­tures of an ide­al genet­ic medicine. 

The com­plete capa­bil­i­ty stack to design, gen­er­ate, and optimize.

Serif is build­ing the full suite of tech­ni­cal capa­bil­i­ties for opti­miz­ing and man­u­fac­tur­ing Mod­i­fied DNA ther­a­peu­tics, aid­ed by AI. We opti­mize DNA and mRNA co-fac­tor sequences and LNPs by learn­ing from mas­sive datasets in a design, build, test, learn cycle, and have devel­oped a scal­able man­u­fac­tur­ing process.

The shape of things to come.

Serif is building a future where DNA becomes the source code for medicines that can be tailored across diseases and scaled for global impact. 

Serif’s initial drug discovery programs are focused on rare diseases and immune programming where Modified DNA’s therapeutic properties offer clear advantages for fulfilling meaningful unmet clinical needs.

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